Abstract: Objective: Cretzfeldt-Jacob Disease (CJD) is a rapidly progressive spongiform disease of the central nervous system. Psychiatric symptoms, though considered rare, can be the presenting symptoms of CJD and impose diagnosis difficulties. We reviewed prospectively our database to identify the frequency of psychiatric symptoms as identifying symptoms among our community.Metods: We included all patients in Sheba Medical Center who were diagnosed with CJD between the years 2006 – 2012.

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