It’s time again for the year’s ten best from NIMH. A year that included a 16-day government shutdown and a 5.2 percent sequester also saw some outstanding scientific breakthroughs and historic changes in policy.
Importance No medication has been established as an efficacious treatment for cocaine dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine system by topiramate—a glutamate receptor antagonist and ?-aminobutyric acid receptor agonist—would result in efficacious treatment for cocaine dependence compared with placebo. Objective To determine the efficacy of topiramate vs placebo as a treatment for cocaine dependence.