Importance A major obstacle to the identification of the neurobiological correlates of schizophrenia is the substantial clinical heterogeneity present in this disorder. Dividing schizophrenia into “deficit” and “nondeficit” subtypes may reduce heterogeneity and facilitate identification of neurobiological markers of disease. Objective To determine whether patients with deficit schizophrenia differ from patients with nondeficit schizophrenia and healthy controls in neuroimaging-based measures of white matter tracts and gray matter morphology

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