Importance Advancing paternal age has been linked to autism. Objective To further expand knowledge about the association between paternal age and autism by studying the effect of grandfathers’ age on childhood autism. Design Population-based, multigenerational, case-control study.

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Abstract: Objective: Patients with chronic kidney disease (CKD) who are undergoing maintenance hemodialysis have a higher prevalence of depression than the general population. The underlying cause of this association is unknown, but may be related to accumulation of uremic toxins. Little is known about the association of accumulation of uremic toxins and depression in hemodialysis patients.Method: We conducted a cross-sectional study of 209 CKD patients from a single institution to evaluate the associations of a soluble small uremic toxin (urea), a soluble large uremic toxin (?2 microglobulin) and two protein-bound uremic toxins [total p-cresol sulfate (PCS) and indoxyl sulfate (IS)] with the presence of depression.Results: A total of 47 patients (22.4%) had depression.

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