The current issue of JAMA Psychiatry includes an important article on premature mortality among patients with traumatic brain injury (TBI) in Sweden between 1969 and 2009. According to the study by Fazel et al, among 218?300 patients with a TBI compared with age- and sex-matched controls without brain injury (10 to 1 match, n?=?2?163?190) and unaffected siblings of TBI patients (n?=?150?513), there was a 3-fold increased odds of all-cause mortality, adjusted for sociodemographic confounders (adjusted odds ratio [aOR],?3.2; 95% CI, 3.0-3.4), among patients who survived at least 6 months after TBI compared with general population controls or unaffected siblings (aOR, 2.6; 95% CI, 2.3-2.8).

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Director’s Blog About a decade ago NIH held a series of workshops to develop a Roadmap for Biomedical Research. We brought experts to Bethesda to suggest new directions for technology development, training, and a range of other areas. In one such meeting, on re-engineering clinical research, many of the nation’s leading clinical scientists debated how to improve our approach to research on diseases.

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Importance Advancing paternal age has been linked to autism. Objective To further expand knowledge about the association between paternal age and autism by studying the effect of grandfathers’ age on childhood autism. Design Population-based, multigenerational, case-control study.

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