Importance Exposure to trauma increases the risk for developing threat (ie, fear) symptoms, such as reexperiencing and hyperarousal symptoms, and loss (ie, dysphoria) symptoms, such as emotional numbing and depressive symptoms. While preclinical data have implicated the activated dynorphin/?-opioid receptor (KOR) system in relation to these symptoms, the role of the KOR system in mediating these phenotypes in humans is unknown. Elucidation of molecular targets implicated in threat and loss symptoms is important because it can help inform the development of novel, mechanism-based treatments for trauma-related psychopathology.

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Importance Posttraumatic stress disorder (PTSD) appears to increase obesity risk but the pathways by which PTSD leads to weight gain are not known. Identification of the links between PTSD and obesogenic eating behaviors is necessary to clarify this pathway and inform development of obesity prevention strategies in PTSD-affected populations. Objective To determine whether women with PTSD symptoms are more likely to report food addiction, a measure of perceived dependence on food, than women without PTSD symptoms

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Director’s Blog I don’t know why or how April 25th, the day after Earth Day and the day before Save the Frogs Day (really), was named National DNA Day, but once again we have a reason to celebrate the basic language of biology. In fact, this has been a good year for DNA—that 3 billion base-pair long sequence of nucleotides which constitute the building blocks for the 23 pairs of chromosomes found in almost every human cell.

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Abstract: Objective: The aims of this study were 1) to assess the long-term effects of a collaborative care intervention for patients with depression on process of care outcomes, and 2) to describe whether case management was continued after the end of the original one-year intervention.Methods: This 24-month follow-up of a randomized controlled trial took place 12months after the end of the 1-year intervention. Data collection occurred by means of self-rating questionnaires and from medical records.

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Importance Few studies have examined the curtailment of reproduction (ie, stoppage) after the diagnosis of a child with autism spectrum disorder (ASD). Objective To examine stoppage in a large, population-based cohort of families in which a child has received a diagnosis of ASD. Design, Setting, and Participants Individuals with ASD born from January 1, 1990, through December 31, 2003, were identified in the California Department of Developmental Services records, which were then linked to state birth certificates to identify full sibs and half-sibs and to obtain information on birth order and demographics

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Abstract: Objective: Depression is one of the most common mental illnesses. The reliability and the validity of the Patient Health Questionnaire (PHQ)-9, a depression screening tool, have not been examined in the general population in China.

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Abstract: Objective: The aim of this study was to quantify the effects of psychiatric disorders on major surgery outcomes and care resource use.Methods: This study adopted a retrospective cohort study design. The samples consisted of hospital stays.

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Abstract: Objective: Project TEACH provides training, consultation and referral support to build child and adolescent mental health (MH) expertise among primary care providers (PCPs) . This study describes how TEACH engages PCP, how program components lead to changes in practice, and how contextual factors influence sustainability.Method: 30 PCPs randomly selected from 139 trained PCPs and 10 PCPs from 143 registered with TEACH but not yet trained completed semi-structured interviews.

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Abstract: Objective: Depression is a highly prevalent disorder that is associated with disability. The aim of this study was to determine the relationship between depression and hyperlipidemia, and whether the onset of depression is associated with administering statins to patients with hyperlipidemia.Material and Methods: The data analyzed in this study were retrieved from the National Health Insurance Research Database (NHIRD) in Taiwan.

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Importance The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) is a multicomponent study designed to generate actionable recommendations to reduce Army suicides and increase knowledge of risk and resilience factors for suicidality. Objectives To present data on prevalence, trends, and basic sociodemographic and Army experience correlates of suicides and accident deaths among active duty Regular Army soldiers between January 1, 2004, and December 31, 2009, and thereby establish a foundation for future Army STARRS investigations.

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