Director’s Blog It’s difficult to overstate the impact that genomic medicine is having on biomedical research and practice. For cancer diagnostics, rare disease therapeutics, and fields like microbiomics and infectious diseases, the advent of cheap, fast, precise genomic sequencing has been a game changer. What about mental disorders

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Importance In 2011, an estimated 26.8 million US adults used prescription medications for mental illness. Objective To estimate the numbers and rates of adverse drug event (ADE) emergency department (ED) visits involving psychiatric medications among US adults between January 1, 2009, and December 31, 2011.

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Importance Posttraumatic stress disorder (PTSD) occurs in about 8% of pregnant women. Stressful conditions, including PTSD, are inconsistently linked to preterm birth. Psychotropic treatment has been frequently associated with preterm birth.

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Syphilis has been called the “great imitator” because of the plethora of signs and symptoms it presents . Neurosyphilis can present with neuropsychiatric symptoms ranging from abnormal pupillary reflex to complex constellations manifesting cognitive, psychotic, and mood dysfunction . However, some patients remain asymptomatic.

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Importance Psychosis-risk studies have examined help-seeking adolescents and young adults. Population-based studies evaluating psychotic symptoms and neurocognitive performance across childhood are needed for “growth charting” cognitive development.

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In a previous post I described the growing contrast between the patient community for whom “time = lives” and the academic community for whom “success = papers and grant funding.” This apparent clash of cultures is important for NIMH. Each year, we spend roughly $1B of taxpayer funds to support research in academia.

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Abstract: Objective: We describe risk factors associated with patients experiencing physical restraint or seclusion in the psychiatric emergency service (PES).Methods: We retrospectively reviewed medical records, nursing logs and quality assurance data for all adult patient encounters in a PES over a 12-month period (June 1, 2011–May 31, 2012). Descriptors included demographic characteristics, diagnoses, laboratory values, and clinician ratings of symptom severity. ?2 and multivariate logistic regression analyses were performed.Results: Restraint/seclusion occurred in 14% of 5335 patient encounters

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Abstract: Objective: To review the current evidence about psychiatric symptoms in Wilson’s disease (WD).Method: We searched Ovid, PsychInfo, CINHAL and PubMed databases from May 1946 to May 2012 using the key words Wilson(‘s) disease in combination with psychiatry, psychiatric, psychosis, schizophrenia, depression, mania, bipolar, mood, anxiety, personality and behavior.Results: Psychiatric symptoms occur before, concurrent with or after the diagnosis and treatment for WD. Thirty to forty percent of patients have psychiatric manifestations at the time of diagnosis, and 20% had seen a psychiatrist prior to their WD diagnosis.

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Abstract: Objective: We aimed to determine Axis I psychiatric disorders in women with hyperemesis gravidarum (HG) and to follow up the course of psychiatric disorder and its association with nausea and vomiting (NV) during pregnancy.Methods: The study sample was composed of 47 patients with HG. Psychiatric interviews were conducted using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID-I).

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Abstract: Few studies have shown that topiramate may induce psychiatric symptoms and metabolic disorders, respectively. Here, we reported a 13-year-old female who presented with topiramate-induced hallucinations and comorbid renal tubular acidosis. She had a history of psychiatric illness and had been taking the medication for 3 months without prior side effects.

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