Director’s Blog One of the most influential trials in cardiology over the past 25 years was the GISSI 1 study, which demonstrated the beneficial effects of administering a medication called streptokinase after a heart attack. 2 GISSI involved more than 11, 000 patients in 176 coronary care units over 17 months. Its total cost was less than $500, 000.

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Director’s Blog Julius Axelrod was one of NIMH’s greatest scientists and mentors for five decades until his death in 2004 at age 92. In addition to his many discoveries – which led to his 1970 Nobel Prize – Julie, as he was known, was famous for his aphorisms.

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Director’s Blog In a wonderful new paper in Science , Jordi Quoidbach, Dan Gilbert, and Tim Wilson describe the “end of history illusion.” 1 This is not about the Mayan calendar or a Y2K syndrome. These scientists studied 19,000 people across six studies to answer a simple question: why do people so often make decisions that their future selves regret? Their results show that people consistently report that they have changed substantially in the past decade and just as consistently predict that they will not change nearly as much in the next decade

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Director’s Blog In a commentary just published on innovation in health care, Narayan and colleagues describe the need for integrated solutions to mental health care. 1 Moving beyond “magic bullets” and the magical thinking of a single intervention for a complex problem, they recommend a comprehensive model that includes early detection, better access to care, monitoring, and patient-reported outcomes. None of this would be particularly innovative, except that Narayan and his colleagues all work for a pharmaceutical company.

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