Director’s Blog Each year at this time, the Kavli Foundation announces its annual scientific prizes. In contrast to the Nobel Prizes, the Kavli Prizes cover three focal areas of science: astrophysics, nanoscience, and neuroscience. Fred Kavli, who died recently, described these prizes as recognizing those who work on “the biggest, the smallest, and the most complex.” This year’s awards in neuroscience, to Brenda Milner, John O’Keefe, and Marcus Raichle, continue the tradition of recognizing those who embrace complexity.

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Abstract: Objective: Project TEACH provides training, consultation and referral support to build child and adolescent mental health (MH) expertise among primary care providers (PCPs) . This study describes how TEACH engages PCP, how program components lead to changes in practice, and how contextual factors influence sustainability.Method: 30 PCPs randomly selected from 139 trained PCPs and 10 PCPs from 143 registered with TEACH but not yet trained completed semi-structured interviews.

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Last week I attended the Partners for Cure (P4C) meeting in New York. This is an annual meetup for an odd mix of academic scientists, advocacy groups, venture capitalists, social entrepreneurs, and biotech-pharma folks.

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One worked for the CIA as a code breaker. Another was an electrical engineer designing high tech circuits.

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Importance Established nosology identifies schizoaffective disorder as a distinct category with boundaries separating it from mood disorders with psychosis and from schizophrenia. Alternative models argue for a single boundary distinguishing mood disorders with psychosis from schizophrenia (kraepelinian dichotomy) or a continuous spectrum from affective to nonaffective psychosis. Objective To identify natural boundaries within psychotic disorders by evaluating associations between symptom course and long-term outcome

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Director’s Blog Meredith, a 15-year-old high school student from San Diego, wrote this year’s breakthrough paper on modeling global epidemics. An 11-year-old boy from upstate New York solved a problem in protein folding using a computer game called Foldit.

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Director’s Blog The physicist and mathematician Freeman Dyson once noted, “New directions in science are launched by new tools much more often than by new concepts.” 1 This week marks the publication of a new tool that may alter the way we look at the brain. Karl Deisseroth and his colleagues at Stanford University have developed a method they call CLARITY. Yes, CLARITY is an acronym, for Clear Lipid-exchanged Anatomically Rigid Imaging/immunostaining-compatible Tissue hYdrogel.

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Director’s Blog In February 2009, a recently inaugurated President Obama signed the American Recovery and Reinvestment Act (ARRA) to invest $787 billion to create jobs, spur the economy, and foster transparency in government spending. About $10 billion of these funds were allocated to NIH for spending in 2009 and 2010. After several years of budgets not keeping up with inflation, NIH welcomed these funds as a chance for the biomedical research community to be part of the ARRA mission.

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Director’s Blog This is the time of March Madness, Daylight Savings Time, and what Emily Dickinson famously called the “month of expectation.” March is also Brain Awareness Month, an annual celebration with school visits, community lectures, and lab tours to introduce the public to the mind-blowing world of neuroscience. A list of Brain Awareness events can be found at http://www.dana.org/brainweek where you will also find that March 10 -16 is the peak for related public events around the world. Since NIMH began focusing on mental disorders as brain disorders nearly two decades ago, educating people about the brain has been a priority for us.

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Director’s Blog In another week or so, I will have been director of NIMH for ten years. This is longer than any previous director dating back to the inaugural director, Bob Felix, who served from 1949 to1964. In leadership, longevity is not necessarily a virtue but it does guarantee perspective

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