Importance The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified. Objectives First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to differentiate UD and BD using multivariate pattern classification techniques.

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For pediatricians and parents, one of the most important tools is decidedly low tech. The growth chart, a simple graph of the trajectory of the normal range of height, weight, and head circumference across age, is a vital tool for detecting problems in development. Even when a child is in the normal range, identifying a change from the 80 th percentile at age 6 to the 20 th percentile at age 8 can indicate a problem.

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Director’s Blog In recent months, there has been a growing global interest in brain science. The President called attention to the effort to map the human brain in his State of the Union address, the European Union recently announced its largest scientific award (1 billion euros) for the Human Brain Project , and private foundations such as the Allen Brain Institute and the Kavli Foundation have announced new bold efforts to map the brain. 1 At the same time, there has been an unprecedented national conversation about what role mental illness plays in gun violence

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