Importance Longer-term mortality in individuals who have survived a traumatic brain injury (TBI) is not known. Objectives To examine the relationship between TBI and premature mortality, particularly by external causes, and determine the role of psychiatric comorbidity. Design, Setting, and Patients We studied all persons born in 1954 or later in Sweden who received inpatient and outpatient International Classification of Diseases -based diagnoses of TBI from 1969 to 2009 (n?=?218?300)

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Abstract: Objective: To examine the associations between depressive/anxiety disorders (DAs), perceived health-related quality of life (HRQOL) and mortality in dialysis patients.Methods: Patients were assessed for depressive and DAs with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders. The HRQOL was assessed with the Medical Outcome Short Form 36 (MOS SF-36), and the Beck Depression Inventory and Hospital Anxiety and Depression Scale were also applied. Sociodemographic, clinical and laboratory data were also collected.Results: Patients with depressive disorders reported more impaired HRQOL on four of the eight subscales, while those with a depressive disorder comorbid with DA reported more impairment on all MOS SF-36 subscales compared to those without any psychiatric disorder.

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Director’s Blog About a decade ago NIH held a series of workshops to develop a Roadmap for Biomedical Research. We brought experts to Bethesda to suggest new directions for technology development, training, and a range of other areas. In one such meeting, on re-engineering clinical research, many of the nation’s leading clinical scientists debated how to improve our approach to research on diseases.

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Abstract: Context: Delirium is prevalent in the intensive care unit (ICU) and has been associated with negative clinical outcomes. However, a quantitative and systematic assessment of published studies has not been conducted.Objective: Meta-analysis of clinical observational studies was performed to investigate the association between delirium and clinical outcomes.Data sources and study selection: Relevant studies were identified by investigators from databases including Medline, Embase, OVID and EBSCO from inception to May 2012.

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