A small number of older studies have demonstrated efficacy for a few antidepressants in cancer care – namely mianserin, fluoxetine and paroxetine – but we lack an evidence base for most of the currently used antidepressants. In their systematic review and meta-analysis in this issue of the role of antidepressants in the treatment of cancer-related depression, Riblet, Larson, Watts and Holtzheimer call for high quality randomized clinical trials that properly examine the efficacy, tolerability and safety of modern day antidepressants .

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Eighteen states and the District of Columbia have legalized possession and use of medical marijuana. Registries from these state-approved programs suggest that up to 94% of participating patients are registered for severe or chronic pain .

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Importance No medication has been established as an efficacious treatment for cocaine dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine system by topiramate—a glutamate receptor antagonist and ?-aminobutyric acid receptor agonist—would result in efficacious treatment for cocaine dependence compared with placebo. Objective To determine the efficacy of topiramate vs placebo as a treatment for cocaine dependence.

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Abstract: Objective: Premenstrual onset psychosis is a rare condition of unknown etiology for which no treatment trials have been conducted and whose existence as a definitive diagnosis continues to be debated. The literature includes individual case reports and small case series, leaving psychiatrists to make decisions about prescribing antipsychotic agents on a case-by-case basis.

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Abstract: Background: Outpatient psychiatric treatment provides both psychotherapy and pharmacotherapy for a large portion of psychiatric patients. Dropping out, or early termination of treatment, may be considered a common barrier to outpatient’s psychiatric treatment. There are limited studies on this issue in Iran

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Clinical trials comparing the efficacy and acceptability of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) and electroconvulsive therapy (ECT) for treating major depression (MD) have yielded conflicting results. As this may have been the result of limited statistical power, we have carried out this meta-analysis to examine this issue.

Source: NIMH Director’s Blog