In this issue of JAMA Psychiatry , Gur et al evaluated differences in age-related neurocognitive test performance and psychosis symptoms in the context of a large population-based cohort. The rationale for this study grew out of observations that psychotic symptoms are relatively common in the general population and that individuals who have had a recent emergence of psychoticlike symptoms, but of subpsychotic intensity, are at increased risk for progressing to full psychosis within a few years of ascertainment. Given that such prodromal cases show neurocognitive deficits similar to those observed in first-episode schizophrenia, the Gur et al study sought to extend evidence of this link to participants with psychotic symptoms as ascertained through primary care, independently of seeking treatment for psychiatric indications.

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Abstract: Objective: Misophonia is a potentially debilitating condition characterized by increased sensitivity to specific sounds, which cause subsequent behavioral and emotional responses. The nature, clinical phenomenology and etiology of misophonia remain unclear, and misophonic clinical presentations are not currently accounted for by existing psychiatric or audiological disorders.Method: We present a case of pediatric misophonia in the context of comorbid obsessive–compulsive disorder and Tourette’s syndrome.Results: Given the interrelationships among obsessive–compulsive spectrum disorders and misophonia, these disorders may share underlying pathophysiology, particularly within the dopaminergic and serotonergic neural systems.

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Importance Neurochemical studies in human aggression point to a modulatory role for a variety of central neurotransmitters. Some of these neurotransmitters play an inhibitory role, while others play a facilitatory role modulating aggression.

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Abstract: Musical hallucinations (MH) have been labeled Oliver Sacks syndrome, and in the majority of cases they occur in the context of a hearing loss. In these instances, they have been described as auditory Charles Bonnet syndrome because they are thought to represent a cortical release phenomenon. Patients with MH tend to have intact reality testing and, as such, the condition may also be described as musical hallucinosis.

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Since the pioneering work on meta-analysis of psychotherapy encompassing hundreds of treatment outcome studies, scores of similar analyses have been published. Meta-analysis represents an important breakthrough by allowing the integration of multiple studies and evaluation of influences on treatment outcome (eg, characteristics of patients and methodological practices) that the individual studies themselves did not or could not address.

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