Importance Genetic markers at the gene encoding the metabotropic glutamate receptor 3 (GRM3) showed allelic association with bipolar disorder. Objective To screen the GRM3 gene and adjacent control regions of genomic DNA in volunteers with bipolar affective disorder for mutations increasing susceptibility to bipolar disorder. Design Sequencing and high-resolution melting curve analysis of DNA followed by genotyping was carried out in 1099 patients with bipolar affective disorder and 1152 healthy comparator individuals.

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Director’s Blog In another week or so, I will have been director of NIMH for ten years. This is longer than any previous director dating back to the inaugural director, Bob Felix, who served from 1949 to1964. In leadership, longevity is not necessarily a virtue but it does guarantee perspective

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Director’s Blog Julius Axelrod was one of NIMH’s greatest scientists and mentors for five decades until his death in 2004 at age 92. In addition to his many discoveries – which led to his 1970 Nobel Prize – Julie, as he was known, was famous for his aphorisms.

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