Importance The neurobiological underpinnings of attention-deficit/hyperactivity disorder (ADHD) and particularly those associated with the persistence of ADHD into adulthood are not yet well understood. The correlation patterns in spontaneous neural fluctuations at rest are known as resting-state functional connectivity (RSFC) and could characterize ADHD-specific connectivity changes. Objective To determine the specific location of possible ADHD-related differences in RSFC between adults diagnosed as having ADHD in childhood and control subjects

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Leading neuroimaging researchers have joked that magnetic resonance spectroscopy (MRS) is a technique of the future and always will be. This skepticism is often well placed because the validation and replication of interesting MRS findings are less frequent than those using other brain imaging modalities. There are multiple reasons for this circumstance: the intrinsic MRS signal to noise ratio is low compared with structural and functional magnetic resonance imaging; specialized magnetic resonance imaging hardware and sequences are required for many MRS experiments, making widespread adoption and standardization difficult; and because MRS yields data on multiple metabolites, it is possible to report secondary findings even if the a priori hypothesis is not confirmed

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