Importance Alterations in glutamatergic neurotransmission have been postulated to be a key pathophysiologic mechanism in schizophrenia. Objective To evaluate hippocampal volumetric measures and neurometabolites in unmedicated patients with schizophrenia and the correlations between these markers.
Director’s Blog There has been a lot of hand wringing recently over the lack of innovation in medication development for mental disorders and the reduced investments from the pharmaceutical industry in the development of psychiatric medications. This may be an era of angst for medication development, but simultaneously there has been a quiet flowering of innovative behavioral treatments. From cognitive therapy developed to reduce repeat suicide attempts, 1 to family-based therapy for those with anorexia nervosa, 2 structured behavioral interventions have been shown to be effective in randomized controlled trials