Bupropion: 5 tips
By Flavio Guzman, MD
Editor, Psychopharmacology Institute
In this psychopharmacology refresher series, from the Psychopharmacology Institute, we discuss key aspects of commonly used medications. Today we start with 5 important concepts about bupropion.
1. Non-serotonergic. It does not influence serotonergic neurotransmission: it is a norepinephrine dopamine reuptake inhibitor without activity on the serotonin reuptake transporter.
Abstract: Objectives: To examine the relationship between antidepressant use in pregnancy and low birth weight (LBW) and preterm birth (PTB).Data Sources and Study Selection: We searched English and non-English language articles via PubMed, CINAHL and PsychINFO (from their start dates through December 1st, 2012). We used the following keywords and their combinations: antidepressant, selective serotonin reuptake inhibitor (SSRI), pregnancy, antenatal, prenatal, birthweight, birth weight, preterm, prematurity, gestational age, fetal growth restriction, intrauterine growth restriction, and small-for-gestational age. Published studies were considered eligible if they examined exposure to antidepressant medication use during pregnancy and reported data on at least one birth outcome of interest: PTB (
Abstract: Objective: The risk of depression in women is greatest at childbearing age. We sought to examine and explain national trends in antidepressant use in pregnant women.Methods: This was a cohort study including pregnant women aged 12–55 who were enrolled in Medicaid during 2000–2007. We examined the proportion of women taking antidepressants during pregnancy by patient characteristics (descriptive), by region (mixed-effects model) and over time (interrupted time series).Results: We identified 1, 106, 757 pregnancies in 47 states; mean age was 23 years, and 60% were nonwhite
Director’s Blog The last days of this long, hot summer are a good time to catch up on a few of the season’s scientific breakthroughs, which have been coming fast and furious during what has been a down time for many people outside of science. What about this week’s story of an increase in spontaneous mutations in children of older dads? We already knew that children with autism and schizophrenia were more likely to have been conceived by fathers over 40