Importance Cigarette smoking leads to upregulation of nicotinic acetylcholine receptors (nAChRs) in the human brain, including the common ?4?2* nAChR subtype. While subjective aspects of tobacco dependence have been extensively examined as predictors of quitting smoking with treatment, no studies to our knowledge have yet reported the relationship between the extent of pretreatment upregulation of nAChRs and smoking cessation. Objective To determine whether the degree of nAChR upregulation in smokers predicts quitting with a standard course of treatment.

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Abstract: Objectives: Paliperidone- Associated Motor TicsMethod: Case reportResults: We report a 30 -year-old man with schizophrenia who developed motor tics (eye-blinking) after treatment of paliperidone up to 15 mg daily.Conclusion: Tic-like symptoms, from simple eye blinking to complex Tourette-like syndrome, may occur during paliperidone treatment, especially with high dose.

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