Abstract: Objective: The aim of this study is to investigate the development of depression during interferon-alpha (IFN-?) therapy and the variations in the expression of the serotonin receptor (5-HTR) and transporter (5-HTT) in hepatitis C patients.Method: Hepatitis C patients (n=277) were given the Mini International Neuropsychiatric Interview at the end of IFN-? therapy. Three polymorphisms were genotyped: the serotonin transporter repeat length polymorphic region [5-HTT gene-linked polymorphic region (5-HTTLPR)], as well as SNPs rs25531 and rs6295, located within the 5-HTTLPR and the transcriptional control region of the 5-HTR1A gene, respectively.Results: The diagnosis of current depression, which was associated with IFN-?-related depression (P

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