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Tanya K. Murphy, MD, Eric A. Storch, PhD, and Melissa S. Strawser, BA

Primary Psychiatry. 2006;13(8):87-89


Dr. Murphy is associate professor and chief of the Division of Child and Adolescent Psychiatry in the Department of Psychiatry, Dr. Storch is assistant professor in the Departments of Psychiatry and Pediatrics, and Ms. Strawser is research assistant in the Department of Psychiatry at the University of Florida in Gainesville.

Disclosure: Dr. Murphy receives research support from Bristol-Myers Squibb, the National Institutes of Health, and the National Institute of Mental Health. Dr. Storch receives research support from the Association for Glycogen Storage Disease, the Barth Syndrome Foundation, the Florida Department of Health, Genentech, the Human Growth Foundation, the National Institutes of Health, and the Obsessive-Compulsive Foundation. Ms. Strawser reports no affiliation with or financial interest in any organization that may pose a conflict of interest.

Please direct all correspondence to: Tanya K. Murphy, MD, Associate Professor and Chief, Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of Florida, JHMHC 100256, Gainesville, FL 32610; Tel: 352-392-3681; Fax: 352-392-2579; E-mail:



Focus Points

• Pediatric autoimmune neuropsychiatric disorders associated with streptococcus is a subtype of obsessive-compulsive disorder and tics associated with an infectious trigger.

• Children with this subtype may be prone to selective serotonin reuptake inhibitor (SSRI)-induced behavioral toxicity.

• Successful treatment may involve lower-than-typical SSRI doses and cognitive-behavioral therapy.