Abstract: Objective: Psychiatric morbidity is quite common in vasovagal syncope (VVS), but findings are sometimes contradictory. Among patients with suspected VVS, up to 40% has a negative response to Head-Up Tilt test (HUT), the cause of syncope remaining unexplained (US).

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Abstract: Object: We sought to explore factors associated with persistence of antidepressant treatment in Taiwan and to compare persistence rates across various antidepressants.Method: This was a retrospective cohort study using medical claims in Taiwan. We collected data of all new antidepressant users with depressive disorder, aged 18 years or older, during the study period from January 1, 1998, to July 4, 2009. Overall antidepressant treatment persistence was defined as undergoing treatment for 180 days without exceeding a 30-day gap

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Abstract: Objective: Patients with chronic kidney disease (CKD) who are undergoing maintenance hemodialysis have a higher prevalence of depression than the general population. The underlying cause of this association is unknown, but may be related to accumulation of uremic toxins. Little is known about the association of accumulation of uremic toxins and depression in hemodialysis patients.Method: We conducted a cross-sectional study of 209 CKD patients from a single institution to evaluate the associations of a soluble small uremic toxin (urea), a soluble large uremic toxin (β2 microglobulin) and two protein-bound uremic toxins [total p-cresol sulfate (PCS) and indoxyl sulfate (IS)] with the presence of depression.Results: A total of 47 patients (22.4%) had depression.

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Abstract: Objective: Cognitive impairment, depression, sleep disorders and impaired quality of life are very common in hemodialysis (HD) patients. However, whether there are any seasonal changes of cognitive impairment, depression, sleep disorders and quality of life in HD patients is not known.Methods: The laboratory parameters, depressive symptoms, health-related quality of life, sleep quality (SQ) and cognitive function, were measured twice.Results: A total of 66 HD patients were enrolled. Pre-dialysis systolic blood pressure (BP) and pre-dialysis diastolic BP were higher, whereas predialysis creatinine and sodium were lower in January compared to July.

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A nicotine vaccine reduces the amount of nicotine that reaches the brain, subsequent cigarette use and cravings, a new study shows. Medscape Medical News

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Low-intensity interventions, such as self-help books and interactive Web sites, may provide a low-cost, first-line treatment option for patients even with severe depression, research suggests. Medscape Medical News

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Director’s Blog In a wonderful new paper in Science , Jordi Quoidbach, Dan Gilbert, and Tim Wilson describe the “end of history illusion.” 1 This is not about the Mayan calendar or a Y2K syndrome. These scientists studied 19,000 people across six studies to answer a simple question: why do people so often make decisions that their future selves regret? Their results show that people consistently report that they have changed substantially in the past decade and just as consistently predict that they will not change nearly as much in the next decade

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Director’s Blog Let’s start with some good news. Over the past few decades in the United States, we have seen dramatic reductions in mortality due to coronary artery disease (an over 60 percent reduction, with 1.1 millions deaths averted each year), AIDS (a 40 percent reduction, with over 30,000 deaths averted each year), and stroke (a 30 percent reduction, with over 20,000 deaths averted each year). Indeed, last month AIDS was declared a chronic disease, recognizing that a young person who becomes infected with HIV will likely survive for decades and die of other causes

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