Antipsychotics with a high binding affinity of alpha-2-adrenergic and M1-muscarinic receptors may increase stroke risk in the elderly — at least in the short term, new research suggests. Medscape Medical News

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An FDA advisory panel concluded that scientific data support approval of Probuphine subdermal implant for maintenance treatment of opioid dependence, but voice some safety concerns.

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Director’s Blog Some moments in science are so transformative that they spill out of the usual academic circles to become headlines in the New York Times and, for a day or two, part of a public conversation. This summer we had two such stories from diverse areas of science: the Curiosity landing on Mars and the report of spontaneous mutations transmitted by older fathers. Earlier this month another report – actually 30 separate papers – marked a transformative moment in our discovery of the genome.

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Director’s Blog NIMH just reached a milestone — our first grant was awarded 65 years ago last month. Rather than celebrating, this anniversary has been allowed to pass quietly. With so much progress in genomics and neuroscience, we at NIMH have mostly been trying to keep up

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Abstract: Objective: Wolff–Parkinson–White (WPW) syndrome is characterized by premature ventricular excitation due to the presence of an abnormal accessory pathway. Electrocardiography (ECG) of patients with WPW syndrome portrays a short PR interval and a wide QRS interval with a delta wave.Methods: Herein, we report the case of a patient with schizophrenia who developed a wide QRS interval with a delta wave immediately following electroconvulsive therapy (ECT).Results: Initially, the delta wave disappeared within 2 days after ECT. However, the duration of the delta wave increased exponentially to 4 months when ECT was repeated.Conclusion: Although the patient’s cardiocirculatory dynamics remained normal, we continued to monitor her ECG until the delta wave disappeared because WPW syndrome can lead to serious arrhythmia.

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Abstract: Objective: Data on psychiatric morbidity in high-risk pregnant Singaporean women are limited. This study aimed to establish the prevalence of antenatal depression and anxiety in high-risk pregnancies, compare the prevalence of antenatal depression in high-risk pregnancies vs.

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Abstract: Objective: The safety of concurrent mood stabilizers during the course of electroconvulsive therapy (ECT) is yet to be clearly established. Delirium with concurrent administration of ECT and lithium carbonate is described in this case report.Methods: A 30-year-old male with a past history of significant head injury developed delirium during the course of bitemporal ECT.Results: The clinical picture and the details of the cognitive impairment have been discussed in the report with a focus on relationship between the lithium carbonate administration and the concurrent ECT.Conclusion: Patients with preexisting organic brain damage could be prone to develop the cognitive adverse effect while on a combination of lithium and ECT.

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Abstract: Context: Delirium is prevalent in the intensive care unit (ICU) and has been associated with negative clinical outcomes. However, a quantitative and systematic assessment of published studies has not been conducted.Objective: Meta-analysis of clinical observational studies was performed to investigate the association between delirium and clinical outcomes.Data sources and study selection: Relevant studies were identified by investigators from databases including Medline, Embase, OVID and EBSCO from inception to May 2012.

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