In the above article, the definition of “Incidence of hyperlipidemia” was omitted. The definition is as follows: Both schizophrenic patients and the general population with new cases of hyperlipidemia (with one diagnosis of hyperlipidemia and with medications for treatment of hyperlipidemia) from 2006 to 2008 for this fixed cohort were defined as incident hyperlipidemia.

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Conduct problems and hurtful and uncaring behaviors in children as young as 6 are harbingers of violent and nonviolent criminal convictions in young adulthood. Medscape Medical News

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Director’s Blog Today, on World Suicide Prevention Awareness Day, an updated National Strategy for Suicide Prevention is being released amidst a public health landscape that has changed thanks in part to the focus brought to suicide by the first national strategy issued 11 years ago. Since the first version was issued, the Suicide Prevention Lifeline was established, Federal and State legislation has been passed that advances suicide prevention planning and programming, and the Suicide Prevention Resource Center was established, among other efforts.

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Director’s Blog In recent months, there has been a growing global interest in brain science. The President called attention to the effort to map the human brain in his State of the Union address, the European Union recently announced its largest scientific award (1 billion euros) for the Human Brain Project , and private foundations such as the Allen Brain Institute and the Kavli Foundation have announced new bold efforts to map the brain. 1 At the same time, there has been an unprecedented national conversation about what role mental illness plays in gun violence

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Abstract: Objective: Aquagenic pruritus is the development of severe, prickling-like skin discomfort without observable skin lesions that is evoked by contact with water at any temperature.Method: This is a case report of a man presenting with aquagenic pruritus after starting clomipramine treatment for anxiety and depression.Results: The patient’s aquagenic pruritus resolved after discontinuing the clomipramine but reemerged when treatment was restarted.Conclusions: A greater awareness and knowledge about aquagenic pruritus among physicians could help improve the clinical recognition and management of this clinical entity.

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Abstract: Objective: Despite the remarkable improvements in pharmacologic treatment efficacy for hepatitis C (HCV) reported in published clinical trials, published research suggests that, in “real-world” patient care, these medical outcomes may be difficult to achieve. This review was undertaken to summarize recent experience in the treatment of HCV in clinical settings, examining the course of patients through the stages of treatment and barriers to treatment encountered.Method: A comprehensive and representative review of the relevant literature was undertaken to examine HCV treatment experience outside of clinical trials in the last decade. This review found 25 unique studies with data on course of treatment and/or barriers to treatment in samples of patients with HCV not preselected for inclusion in clinical trials.Results: Results were examined separately for samples selected for HCV infection versus HCV/HIV coinfection

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We thank Ms. McGuire and Drs. Moutier, Downs and Zisook for highlighting the innovative and multidimensional University of California, San Diego (UCSD) School of Medicine Suicide Prevention and Depression Awareness Program.

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Abstract: Objective: The objective was to examine whether preexisting cognitive function rather than cognitive decline associated with intraoperative procedures may predict change in behavioral functional capacity in patients 1 year after cardiac surgery.Method: Forty-five patients completed a cognitive evaluation, including the Trail Making Test part B (TMT-B) for attention and psychomotor speed, the Memory with 10-s interference for working memory, the Digit Span test for short-term memory and the Instrumental Activities of Daily Living (IADLs) questionnaire for behavioral functional capacity, before surgery and 1 year after cardiac surgery.Results: Sixteen patients (36%) exhibited cognitive decline after cardiac surgery. Preoperative scores on TMT-B significantly predicted change in behavioral functional capacity as measured by IADLs (beta=0.371, P .08).Conclusions: Preexisting cognitive dysfunctions as assessed by TMT-B can be a marker of preoperative brain dysfunction, which, in turn, in addition to brain damage caused by cardiac surgery procedures, may further predispose patients to poor behavioral functional capacity and outcome 1 year after surgery.

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