Importance The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified. Objectives First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to differentiate UD and BD using multivariate pattern classification techniques.
Importance Despite a remarkable co-occurrence of obsessive-compulsive disorder (OCD) and schizophrenia, little is known about the clinical and etiological relationship of these 2 disorders. Exploring the degree to which these disorders share etiological factors might provide useful implications for clinicians, researchers, and those with the disorders. Objectives To assess whether patients with OCD experience an enhanced risk of developing schizophrenia and schizophrenia spectrum disorders and to determine whether a family history of OCD constitutes a risk factor for schizophrenia and schizophrenia spectrum disorders.
Since its initial discovery in the 1800s until recently, myelin was considered a simple insulator for axons, and its formation was believed to be regulated by predetermined biochemical and cellular processes. Moreover, both oligodendrocytes and the myelin they generate were considered to be static components of the nervous system. However, recent studies have revealed that oligodendrocyte development and myelination are highly dynamic processes that continue throughout adult life, are influenced by experience and neuronal activity, and contribute to cognitive function and behavior
Abstract: A 19-year-old woman with a medical history of depressive mood arrived and was treated with lamotrigine at 25 mg/day. On day 10, a high fever of 39.3°C and a diffuse, erythematous, pruritic full-body rash involving the palms of her hands and the soles of her feet developed, and she was diagnosed with Stevens-Johnson syndrome (SJS). On day 17, white blood cell count (WBC) result was 1,240/?l with 54.1% neutrophils (670/?l), and the WBC decreased to 840/?l with 60.7% neutrophils (510/?l) on day 18.
Abstract: Objective: Primary care screening programs for mental health disorders are designed to detect patients who might benefit from treatment. As such, the utility of these programs is predicated on the actions that take place in response to a positive screen.
Director’s Blog An understanding of how memory works has been the Holy Grail of psychology for the past century. Over the past fifty years, neuroscientists have joined that quest, searching for how and where the brain forms new memories and retrieves old ones.
Importance The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene ( ZNF804A ) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. Objectives To characterize ZNF804A expression in human brain and to investigate how it changes across the life span and how it is affected by rs1344706, schizophrenia, bipolar disorder, and major depressive disorder.
Abstract: Objective: Previous epidemiologic studies have documented a link between anxiety disorders and ulcer among adults. Few studies have examined these associations over time and little is understood about the pathways underlying these relationships.Method: Data were drawn from n=2101 adult participants in the Midlife Development in the United States I and II. Data on ulcer diagnoses were collected through self-report: among participants in the current sample, 38 reported ulcer at Waves 1 and 2 (prevalent ulcer), and 18 reported ulcer at Wave 2 but not at Wave 1 (incident ulcer)
Director’s Blog It’s difficult to overstate the impact that genomic medicine is having on biomedical research and practice. For cancer diagnostics, rare disease therapeutics, and fields like microbiomics and infectious diseases, the advent of cheap, fast, precise genomic sequencing has been a game changer. What about mental disorders
Abstract: Background: The psychopathological and clinical characteristics of adult patients with epilepsy attending our neurology clinic was evaluated to determine prevalence of psychopathology and its associated factors towards improving services and initiating collaborative care which is currently non-existent.Methods: The study was a 2 stage procedure conducted over one year using the General Health Questionnaire (GHQ-12) in the first stage and Schedule for Clinical Assessment in Neuropsychiatry (SCAN) in the second stage. Diagnosis of psychiatric disorders was based on ICD-10 criteria.Results: Sixty-three patients were interviewed. Mean age was 34.43±13.7 years; more than half of the patients had less than one seizure episode per month