Abstract: Context: Delirium is prevalent in the intensive care unit (ICU) and has been associated with negative clinical outcomes. However, a quantitative and systematic assessment of published studies has not been conducted.Objective: Meta-analysis of clinical observational studies was performed to investigate the association between delirium and clinical outcomes.Data sources and study selection: Relevant studies were identified by investigators from databases including Medline, Embase, OVID and EBSCO from inception to May 2012.

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