Importance Tractography studies investigating white matter (WM) abnormalities in patients with bipolar disorder have yielded heterogeneous results owing to small sample sizes. The small size limits their generalizability, a critical issue for neuroimaging studies of biomarkers of bipolar I disorder (BPI). Objectives To study WM abnormalities using whole-brain tractography in a large international multicenter sample of BPI patients and to compare these alterations between patients with or without a history of psychotic features during mood episodes.
Importance Genetic factors contribute to risk for bipolar disorder (BP), but its pathogenesis remains poorly understood. A focus on measuring multisystem quantitative traits that may be components of BP psychopathology may enable genetic dissection of this complex disorder, and investigation of extended pedigrees from genetically isolated populations may facilitate the detection of specific genetic variants that affect BP as well as its component phenotypes. Objective To identify quantitative neurocognitive, temperament-related, and neuroanatomical phenotypes that appear heritable and associated with severe BP (bipolar I disorder [BP-I]) and therefore suitable for genetic linkage and association studies aimed at identifying variants contributing to BP-I risk.
Syphilis has been called the “great imitator” because of the plethora of signs and symptoms it presents . Neurosyphilis can present with neuropsychiatric symptoms ranging from abnormal pupillary reflex to complex constellations manifesting cognitive, psychotic, and mood dysfunction . However, some patients remain asymptomatic.
Abstract: Objective: Cretzfeldt-Jacob Disease (CJD) is a rapidly progressive spongiform disease of the central nervous system. Psychiatric symptoms, though considered rare, can be the presenting symptoms of CJD and impose diagnosis difficulties. We reviewed prospectively our database to identify the frequency of psychiatric symptoms as identifying symptoms among our community.Metods: We included all patients in Sheba Medical Center who were diagnosed with CJD between the years 2006 – 2012.
Importance Each year, millions of persons worldwide seek compensation for transport accident and workplace injuries. Previous research suggests that these claimants have worse long-term health outcomes than persons whose injuries fall outside compensation schemes. However, existing studies have substantial methodological weaknesses and have not identified which aspects of the claiming experience may drive these effects.
Neurobiological research in psychiatry has increasingly placed emphasis on understanding how neural systems go awry in psychiatric disorders. Toward this end, advanced imaging methods go beyond the study of isolated brain areas, probing the connections within neural networks. Diffusion imaging (DI) assesses white matter (WM) microstructure, informing us about the physical state of these connections (the wiring within a system)
People with serious mental illness (SMI) experience higher rates of chronic care conditions (CCCs) (e.g., cardiovascular disease, diabetes, hypertension,) and experience many years of lost life compared to the general population . We define SMI as meeting criteria for one DSM-IV/SCID diagnosis (e.g., schizophrenia, bipolar disorder), other than a substance use disorder, and having serious functional limitations . Poor management of CCCs is a major source of disability, and can lead to unnecessary health care expenditures including emergency room use , and increased mortality
Abstract: Objective: To describe eating disorders inpatients with severe medical complications and elucidate the problems in managing them on a psychiatric ward.Method: Of the 111 eating disorders patients hospitalized on our psychiatric ward from January 2005 to December 2012, 9 had eating disorders with severe medical complications. Through chart review and computerized data collection, we retrospectively evaluated patient clinical data.Result: All 9 patients were women, with a mean age of 22.4±5.7 years, mean body weight of 26.2±3.0 kg, and mean body mass index of 10.5±1.5 on admission. Severe medical complications commonly seen were severe hypoglycemia, refeeding syndrome, coagulation abnormality, and severe liver dysfunction.
For pediatricians and parents, one of the most important tools is decidedly low tech. The growth chart, a simple graph of the trajectory of the normal range of height, weight, and head circumference across age, is a vital tool for detecting problems in development. Even when a child is in the normal range, identifying a change from the 80 th percentile at age 6 to the 20 th percentile at age 8 can indicate a problem.
Opioid abuse is reaching epidemic proportions in the United States. The consequences of opioid abuse and dependence include emergency department visits, premature death, HIV, hepatitis, criminal activity, lost workdays, and economic costs that in the United States exceed $56 billion annually. Agonist maintenance is the most efficacious treatment for opioid dependence and dramatically reduces morbidity, mortality, and spread of infectious disease