Director’s Blog In 2007, Caryn James wrote in The New York Times that “autism has become to disorders what Africa is to social issues.” 1 This statement was intended to emphasize the emerging public recognition of autism during the preceding decade. But it was also a prescient comparison, for in the years since 2007, autism and Africa have become highly contentious topics with emerging movements that have polarized those involved and confused the broader public.

Read >

Director’s Blog In a commentary just published on innovation in health care, Narayan and colleagues describe the need for integrated solutions to mental health care. 1 Moving beyond “magic bullets” and the magical thinking of a single intervention for a complex problem, they recommend a comprehensive model that includes early detection, better access to care, monitoring, and patient-reported outcomes. None of this would be particularly innovative, except that Narayan and his colleagues all work for a pharmaceutical company.

Read >

Abstract: Objective: The aim of this study is to assess the quality of life (QoL), family burden and psychiatric disorders in first-degree relatives of patients with obsessive–compulsive disorder (OCD) and to compare them with healthy controls and their relatives.Methods: Forty patients with OCD and 47 of their first-degree relatives as well as 40 healthy subjects and 45 of their first-degree relatives were recruited in this study. OCD and comorbid anxiety or mood disorders were determined by means of the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders. Comorbid Axis II disorders were diagnosed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition Personality Disorders.

Read >

Importance Untreated depression during pregnancy has been associated with increased morbidity and mortality for both mother and child and, as such, optimal treatment strategies are required for this population. Context There are conflicting data regarding potential risks of prenatal antidepressant treatment. Objective To determine whether prenatal antidepressant exposure is associated with risk for selected adverse pregnancy or delivery outcomes.

Read >

Importance Although increased risk for schizophrenia among immigrants is well established, knowledge of the broader spectrum of psychiatric disorders associated with a foreign migration background is lacking. Objective To examine the full range of psychiatric disorders associated with any type of foreign migration background among persons residing in Denmark, including foreign-born adoptees, first- and second-generation immigrants, native Danes with a history of foreign residence, and persons born abroad to Danish expatriates. Design and Setting Danish population-based cohort study.

Read >

Abstract: Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is a new, severe and possibly life-threatening disorder as illustrated by a 25% mortality or severe disability rate. Its neuropsychiatric presentation closely resembles schizophrenia. In this paper, the relationship of anti-NMDAR encephalitis to schizophrenia and its consequences in Consultation–Liaison service for diagnostic workup in patients with first-episode psychosis are addressed.

Read >

Physician suicides evoke more public interest than most other suicides. Is this because physicians are expected to be superhuman, impeccable and flawless? Do some patients perceive a physician suicide as the ultimate proof of total sacrifice and devotion

Read >

Abstract: Objective: Benzodiazepines (BDZs) safety profiles in pregnancy suggest that the risk of major malformations (MMs) cannot be considered simply as a “class effect”. The aim of this paper was to review and update the available literature on the risks of MMs in women exposed to BDZs in the first trimester of pregnancy.Methods: PubMed was searched for English-language articles, from January 2001 to November 2011, introducing as keywords “teratogens”, “ major malformation”, “foetus”, “infant”, “newborn”, “pregnancy”, in conjunction with “benzodiazepines” as a keyword or BDZ generic name as text words.Results: Twelve studies were selected for the review.

Read >