Director’s Blog When the Mental Health Parity and Addiction Equity Act was signed into law in 2008, after decades of debate, advocates for mental health celebrated what was arguably their most important legislative achievement in 50 years. The new law, with the cumbersome acronym of MHPAEA, had a simple, ambitious goal: treatment for mental illness and substance abuse disorders would be on a par with treatment for all other medical disorders. If insurance companies covered treatments for depression and diabetes, they could not have different requirements or different deductibles or different reimbursement schedules for the two conditions.

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Director’s Blog Imagine for a moment that we had the magic bullet for depression or schizophrenia or anorexia or autism. A single pill, taken once a day, safe and effective, that would immediately and continually keep all of the symptoms at bay.

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Director’s Blog Released today, the World Health Organization (WHO)'s report, ” Preventing Suicide: A global imperative ,” provides the first global view of how often suicide attempts and deaths occur, and how suicide-related behaviors affect all ages, nationalities, economic levels, and cultures. Every year around the world more than 800,000 people die by suicide. Globally, suicide is the second leading cause of death in 15- to 20-year-olds.

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Importance The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified. Objectives First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to differentiate UD and BD using multivariate pattern classification techniques.

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Importance Despite a remarkable co-occurrence of obsessive-compulsive disorder (OCD) and schizophrenia, little is known about the clinical and etiological relationship of these 2 disorders. Exploring the degree to which these disorders share etiological factors might provide useful implications for clinicians, researchers, and those with the disorders. Objectives To assess whether patients with OCD experience an enhanced risk of developing schizophrenia and schizophrenia spectrum disorders and to determine whether a family history of OCD constitutes a risk factor for schizophrenia and schizophrenia spectrum disorders.

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Since its initial discovery in the 1800s until recently, myelin was considered a simple insulator for axons, and its formation was believed to be regulated by predetermined biochemical and cellular processes. Moreover, both oligodendrocytes and the myelin they generate were considered to be static components of the nervous system. However, recent studies have revealed that oligodendrocyte development and myelination are highly dynamic processes that continue throughout adult life, are influenced by experience and neuronal activity, and contribute to cognitive function and behavior

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Abstract: A 19-year-old woman with a medical history of depressive mood arrived and was treated with lamotrigine at 25 mg/day. On day 10, a high fever of 39.3°C and a diffuse, erythematous, pruritic full-body rash involving the palms of her hands and the soles of her feet developed, and she was diagnosed with Stevens-Johnson syndrome (SJS). On day 17, white blood cell count (WBC) result was 1,240/?l with 54.1% neutrophils (670/?l), and the WBC decreased to 840/?l with 60.7% neutrophils (510/?l) on day 18.

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Abstract: Objective: Primary care screening programs for mental health disorders are designed to detect patients who might benefit from treatment. As such, the utility of these programs is predicated on the actions that take place in response to a positive screen.

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Director’s Blog An understanding of how memory works has been the Holy Grail of psychology for the past century. Over the past fifty years, neuroscientists have joined that quest, searching for how and where the brain forms new memories and retrieves old ones.

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Importance The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene ( ZNF804A ) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. Objectives To characterize ZNF804A expression in human brain and to investigate how it changes across the life span and how it is affected by rs1344706, schizophrenia, bipolar disorder, and major depressive disorder.

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