It has been suggested that using organs voluntarily donated by prisoners could help ease the shortage. Bioethicist Art Caplan says it’s wrong on many levels. Medscape Business of Medicine

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A pretreatment PET scan may pave the way past the trial-and-error approach to picking a first-line therapy for major depression, new research hints. Medscape Medical News

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After brief training in mindfulness meditation, specific brain changes that correlate with reduced anxiety are visible on imaging, new research shows. Medscape Medical News

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The CMS has updated its State Operations Manual and produced new mandatory training videos in a renewed effort to reduce use of antipsychotics to treat nursing home patients with dementia. Medscape Medical News

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Older patients with generalized anxiety disorder on maintenance escitalopram have a better chance of avoiding relapse when going off the medication if they are also receiving cognitive behavioral therapy. Reuters Health Information

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There is well-established evidence of a P50 sensory gating deficit in patients of schizophrenia. This gating deficit refers broadly to an inability to prioritize environmental stimuli. More specifically, it refers to an inability to dampen the amplitude of the evoked P50 potential to the second of a pair of identical auditory stimuli presented 500 milliseconds apart. In one study sample, this deficit was observed in 91% of unrelated patients with schizophrenia vs 6% of appropriately matched controls.
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When the DSM-5 is released this month, the diagnostic manual’s first major revision in nearly two decades, there will be a number of changes in the manual’s approach to schizophrenia and other psychotic disorders. Dr. Rajiv Tandon, a member of the DSM-5 Workgroup for Psychotic Disorders, highlights four important changes that will have clinical implications for the diagnosis and treatment of schizophrenia.

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Background This study examined the feasibility and preliminary effectiveness of d -cycloserine (DCS)–augmented cognitive behavioral therapy (CBT) for children and adolescents with difficult-to-treat Obsessive Compulsive Disorder, in a double-blind randomized controlled pilot trial (RCT). Methods Seventeen children and adolescents (aged 8–18 years) with a primary diagnosis of OCD, which was deemed difficult-to-treat, were randomly assigned to either nine sessions of CBT including five sessions of DCS-augmented exposure and response prevention (ERP) [ERP + DCS] or nine sessions of CBT including five sessions of placebo-augmented ERP [ERP + PBO]. Weight-dependent DCS or placebo doses (25 or 50 mg) were taken 1 hour before ERP sessions.

Source: NIMH Director’s Blog

The overuse of smartphones and the Internet may lead to significant problematic behaviors in adolescents, including depression and aggression — and the greater the use, the greater the risk. Medscape Medical News

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Should patients with schizophrenia be screened frequently for cardiometabolic risk factors? Schizophrenia Bulletin

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