Clinical trials comparing the efficacy and acceptability of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) and electroconvulsive therapy (ECT) for treating major depression (MD) have yielded conflicting results. As this may have been the result of limited statistical power, we have carried out this meta-analysis to examine this issue.

Source: NIMH Director’s Blog

Micropharmacology: Treating Disturbances of Mood, Thought, and Behavior as Specific Neurotransmitter Dysregulations Rather Than as Clinical Syndromes

Andrew Edmund Slaby, MD, PhD, MPH

Laurence R. Tancredi, MD, JD


Dr. Slaby is clinical professor of psychiatry at New York University and New York Medical College, both in New York City.

Dr. Tancredi is clinical professor of psychiatry at New York University.

Acknowledgments: The authors report no financial, academic, or other support of this work.



Discovery in the mid-1950s that chlorpromazine alters the thinking of psychotic patients and that tricyclic antidepressants and monoamine oxidase inhibitors impact mood has resulted, in the ensuing decades, in a paradigm shift in our perception of how the human brain functions. Read >