Bupropion: 5 tips

By Flavio Guzman, MD
Editor, Psychopharmacology Institute


In this psychopharmacology refresher series, from the Psychopharmacology Institute, we discuss key aspects of commonly used medications. Today we start with 5 important concepts about bupropion.

1. Non-serotonergic. It does not influence serotonergic neurotransmission: it is a norepinephrine dopamine reuptake inhibitor without activity on the serotonin reuptake transporter.



2. Stimulant effects. Bupropion has stimulating properties. This makes it an interesting option for patients with depression and psychomotor impairment.

3. Different adverse events. Bupropion rarely differs from placebo in regard to sexual side effects, so it is a good option for patients who are concerned about potential sexual side effects from antidepressant treatment.

4. Not associated with weight gain. Bupropion is a good option for patients in which weight gain is a concern. It is not associated with antidepressant-induced weight gain. In fact, current evidence suggests it is associated with weight loss.

5. Seizure risk is a concern. Prescribers need to rule out preexisting relevant CNS disorders before prescribing bupropion.




For access to more video tutorials about bupropion, please visit:
The Psychopharmacology of Bupropion: An Illustrated Overview