Importance Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin has previously been shown to be effective in a double-blind single-site study conducted in Mexico. Objective To evaluate the safety and efficacy of vigabatrin for the treatment of cocaine dependence in a US sample.
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Importance Genetic markers at the gene encoding the metabotropic glutamate receptor 3 (GRM3) showed allelic association with bipolar disorder. Objective To screen the GRM3 gene and adjacent control regions of genomic DNA in volunteers with bipolar affective disorder for mutations increasing susceptibility to bipolar disorder. Design Sequencing and high-resolution melting curve analysis of DNA followed by genotyping was carried out in 1099 patients with bipolar affective disorder and 1152 healthy comparator individuals.
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Clinical trials with positive findings are more likely to be submitted and published than those with negative findings, but negative findings can provide invaluable information, particularly when based on sound methodology. The study by Somoza and colleagues in this issue provides a powerful illustration of the potential value of a negative finding.
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The New York State Psychiatric Association’s class action lawsuit against UnitedHealth Group over parity violations may be a harbinger of more suits to come, says APA. Medscape Medical News
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