Importance Currently, fewer than 40% of patients treated for major depressive disorder achieve remission with initial treatment. Identification of a biological marker that might improve these odds could have significant health and economic impact. Objective To identify a candidate neuroimaging “treatment-specific biomarker” that predicts differential outcome to either medication or psychotherapy
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Importance Mood disorders frequently co-occur with medical diseases that involve inflammatory pathophysiologic mechanisms. Immune responses can affect the brain and might increase the risk of mood disorders, but longitudinal studies of comorbidity are lacking. Objective To estimate the effect of autoimmune diseases and infections on the risk of developing mood disorders
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Since the pioneering work on meta-analysis of psychotherapy encompassing hundreds of treatment outcome studies, scores of similar analyses have been published. Meta-analysis represents an important breakthrough by allowing the integration of multiple studies and evaluation of influences on treatment outcome (eg, characteristics of patients and methodological practices) that the individual studies themselves did not or could not address.
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Should patients with schizophrenia be screened frequently for cardiometabolic risk factors? Schizophrenia Bulletin
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